Pat Wilkerson started his law enforcement career in 1971 as a night clerk with the OSBI. After graduation from the University of Oklahoma in 1974, he became one of the first field agents for the chief medical examiner and was hired by OSBI as an agent in 1977. Upon retirement in 1994, he was appointed US marshal for the Eastern District. In 2002 he became the assistant federal security director for the Transportation Security Administration. In 2012, he was reappointed US marshal for the Eastern District of Oklahoma.